148 ORTHOSTATIC HEMODYNAMICS AND ACCELERATED BRAIN AGING

Abstract Background Impaired recovery of blood pressure (BP) in response to standing up is a prevalent condition older individuals. We evaluated the relationship between hemodynamic responses and brain health adults over 50. Methods Participants from The Irish Longitudinal Study on Aging (TILDA) (n=418) performed an active stand challenge while BP heart rate (HR) were continuously monitored. these parameters was determined as difference measurements taken at 10 s 20 after standing, relation baseline value. biological chronological age using BrainPAD, novel validated measure accelerated ageing. data fitted linear regression models, age, sex, weight, height, cardiac disease prevalence, antihypertensive antidepressant use, smoking status, speed pulse wave velocity covariates. Results Adjusting for sex only, each additional year BrainPAD associated with –0.35 mmHg (95% CI: –0.54 – –0.16, P<.001) change orthostatic systolic recovery. In fully adjusted model, coefficient estimated –0.29 –0.48 –0.10, P<.01). Similarly, increase –0.21 –0.32– P<0.001) –0.14 –0.25– –0.04, P<.01) diastolic recovery, minimally models respectively. HR not significantly BrainPAD. Conclusion These results demonstrate that impaired aging This suggests measured beat-to-beat monitoring, has potential be used marker aging, relying simple procedure devices are easily accessible clinical use.